paediatric anaesthetist
NICOLA GROES CLAUSENM.D PhD
This website is about my professional function as a paediatric anaesthetist and researcher within the field of anaesthesia-related neurotoxicity.
RESEARCHER | SPEAKER | LECTURER
About Me
Paediatric anaesthetist at Odense University Hospital, Dept of Anaesthesia and Intensive Care. Active researcher within optimization of peri-anaesthetic safety of infants and children. Committed speaker and instructor. Part-time employment as a prehospital emergency physician. Facilitation of teamwork and recognizing the value of human resources are a priority in my clinical work.
Executive Board Member ESPA
– The European Society for Paediatric Anaesthesiology
Publications:
Abtracts – Journals -Publications
List of all my publications sorted by year published
2021: The Use of Tablet Computers to Reduce Preoperative Anxiety in Children Before Anesthesia: A Randomized Controlled Study
2020: Blood pressure in Danish children during general anaesthesia: Hypotension in a paediatric population observational (HIPPO) study
2020: Effects of hypothermia and hypothermia combined with hypocapnia on cerebral tissue oxygenation in piglets
2020: Anesthesia Neurotoxicity in the Developing Brain: Basic Studies Relevant for Neonatal or Perinatal Medicine
2019: Effects of moderate and severe hypocapnia
Ringer SK, Clausen NG, Spielmann N, Weiss M. Effects of moderate and severe hypocapnia on intracerebral perfusion and brain tissue oxygenation in piglets. Paediatric anaesthesia. 2019
2019: Anesthesia Neurotoxicity in the Developing Brain:
Clausen NG, Hansen TG, Disma N. Anesthesia Neurotoxicity in the Developing Brain: Basic Studies Relevant for Neonatal or Perinatal Medicine. Clinics in perinatology. 2019;46(4):647-56.
2019: Hypotension and Hypocapnia During General Anesthesia in Piglets
Clausen NG, Antonsen S, Spielmann N, Hansen TG, Weiss M, Ringer SK. Hypotension and Hypocapnia During General Anesthesia in Piglets: Study of S100b as an Acute Biomarker for Cerebral Tissue Injury. Journal of neurosurgical anesthesiology. 2019.
2018 October: Effects of moderate and severe arterial hypotension on intracerebral perfusion and brain tissue oxygenation in piglets.
Br J Anaesth. 2018 Dec;121(6):1308-1315. doi: 10.1016/j.bja.2018.07.041. Epub 2018 Oct 10.
PMID: 30442258
2018 August: Anesthesia and the developing brain: A way forward for laboratory and clinical research.
Paediatr Anaesth. 2018 Sep;28(9):758-763. doi: 10.1111/pan.13455. Epub 2018 Aug 16.
PMID: 30117228
2018 February: Systematic review of the neurocognitive outcomes used in studies of paediatric anaesthesia neurotoxicity.
Br J Anaesth. 2018 Jun;120(6):1255-1273. doi: 10.1016/j.bja.2017.11.107. Epub 2018 Feb 3. Review.
PMID: 29793593
2017 December: Effectiveness of tip rotation in fibreoptic bronchoscopy under different experimental conditions: an in vitro crossover study.
Br J Anaesth. 2017 Dec 1;119(6):1206-1212. doi: 10.1093/bja/aex322.
PMID: 29028928
2017 March: Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe.
Lancet Respir Med. 2017 May;5(5):412-425. doi: 10.1016/S2213-2600(17)30116-9. Epub 2017 Mar 28. Erratum in: Lancet Respir Med. 2017 May;5(5):e19. Lancet Respir Med. 2017 Jun;5(6):e22.
PMID: 28363725>
2016 April: Oral Clefts and Academic Performance in Adolescence: The Impact of Anesthesia-Related Neurotoxicity, Timing of Surgery, and Type of Oral Clefts.
Cleft Palate Craniofac J. 2017 Jul;54(4):371-380. doi: 10.1597/15-185. Epub 2016 Apr 4.
PMID: 27043652
2014: [Potential neurotoxicity of general anaesthetics to the developing brain].
Ugeskr Laeger. 2014;176(34). pii: V12120689. Review. Danish.
PMID: 25293561
2010 February: Risk scoring systems for adults admitted to the emergency department: a systematic review.
Scand J Trauma Resusc Emerg Med. 2010 Feb 11;18:8. doi: 10.1186/1757-7241-18-8. Review.
PMID: 20146829
Curriculum Vitae:
ADVANCED EDUCATION PROGRAM IN PAEDIATRIC ANAESTHESIA SEPTEMBER 2017 - AUGUST 2019
An accordion content areaScandinavian Society of Anaesthesiology and Intensive Care Medicine, SSAI, coordinates an
Inter-Nordic fellowship (training program) in Paediatric Anaesthesia and Intensive Care
Medicine for young Scandinavian specialists in Anaesthesiology:
• 24 months of training in paediatric anaesthesia and intensive care
• 3 months (minimum) of paediatric intensive care medicine during the 2 years
• 1 month of exchange in another county during the 2 years
• 4 theoretical courses
• Assessment after each theoretical course
• Academic project
During the 2 year training period, the following areas will be covered:
• Neonatal anaesthesia
• Anaesthesia for thoracic and cardiovascular surgery
• Anaesthesia for orthopaedic surgery
• Anaesthesia for neurosurgery
• Anaesthesia outside the operation theatre
• Management of a difficult airway
• Management of central (epidural/sacral) and peripheral blocks
• Management of acute and chronic pain
RESEARCH ASSISTANT & FELLOW PEDIATRIC ANESTHESIA AT KINDERSPITAL ZÜRICH SEPTEMBER 2016 - APRIL 2018
EMERGENCY PHYSICIAN APRIL 2015 - PRESENT
PHD FELLOW AT UNIVERSITY OF SOUTHERN DENMARK SEPTEMBER 2014 - DECEMBER 2018
Long term outcome after general anaesthesia in newborns and infants: a Danish follow up study
Hypothesis and outcomes:
The current study aims to investigate, whether GA provided to children up to 1 year of age
causes any long term damage to brain development. We will compare 1) school achievements,
2) presence of psychiatric diagnoses, 3) handicaps of vision and hearing among children, who
on one side have been through surgery and GA within their first year of life and on the other
side to children, who have not.
If GA causes brain damage, we expect these children
– to have poorer grades at school at the national 9th grade exam
– to be more often diagnosed with psychiatric diseases
– to present with visual- and hearing-handicaps more often, than the children, they are
compared to.
Method:
The relations mentioned above will be investigated merely by search on different Danish Civil
Registers and linkage of these data. All children born in DK from 1986-1990 will be identified
in the C R-register and linked to 5 different registers.
We will adjust our data for those factors, that might influence school achievements,
behavioural diagnoses and handicaps: parents’ age and education, the childrens birthweight,
the condition the children needed treatment for in the first place.
Advantages:
The current study is much cheaper than clinical experiments.
No harm is done to children, no inconvenience is imposed on parents or professionals.
The data are already there, hence the results will be available within a reasonable time-frame.
INSTRUCTOR 2014 - PRESENT
ANAESTHESIOLOGIST AT ODENSE UNIVERSITY HOSPITAL MAY 2013 - PRESENT
team training