paediatric anaesthetist

NICOLA GROES CLAUSEN

M.D PhD

This website is about my professional function as a paediatric anaesthetist and researcher within the field of anaesthesia-related neurotoxicity.

 

RESEARCHER | SPEAKER | LECTURER

About Me

 

Paediatric anaesthetist at Odense University Hospital, Dept of Anaesthesia and Intensive Care. Active researcher within optimization of peri-anaesthetic safety of infants and children. Committed speaker and instructor. Part-time employment as a prehospital emergency physician. Facilitation of teamwork and recognizing the value of human resources are a priority in my clinical work.

Executive Board Member ESPA
 – The European Society for Paediatric Anaesthesiology 

 

ESPA
IMG 0892

Publications:

Abtracts – Journals -Publications

List of all my publications sorted by year published

2021: The Use of Tablet Computers to Reduce Preoperative Anxiety in Children Before Anesthesia: A Randomized Controlled Study

2020: Blood pressure in Danish children during general anaesthesia: Hypotension in a paediatric population observational (HIPPO) study

    • PMID: 32589795

 

Background: In Denmark, thousands of infants and children require general anaesthesia annually. Hypotension during general anaesthesia might reduce cerebral blood flow and oxygen delivery to the brain. Safe lower limits of blood pressure are ill defined. The Hypotension in Paediatric Populations Observational study objective was to assess blood pressure in Danish children during general anaesthesia.

    2020: Effects of hypothermia and hypothermia combined with hypocapnia on cerebral tissue oxygenation in piglets

    Background: Hypothermia and its combination with hypocapnia are frequently associated with anesthesia.

      2020: Anesthesia Neurotoxicity in the Developing Brain: Basic Studies Relevant for Neonatal or Perinatal Medicine

      2019: Effects of moderate and severe hypocapnia

      Ringer SK, Clausen NG, Spielmann N, Weiss M. Effects of moderate and severe hypocapnia on intracerebral perfusion and brain tissue oxygenation in piglets. Paediatric anaesthesia. 2019

      2019: Anesthesia Neurotoxicity in the Developing Brain:

      Clausen NG, Hansen TG, Disma N. Anesthesia Neurotoxicity in the Developing Brain: Basic Studies Relevant for Neonatal or Perinatal Medicine. Clinics in perinatology. 2019;46(4):647-56.

      2019: Hypotension and Hypocapnia During General Anesthesia in Piglets

      Clausen NG, Antonsen S, Spielmann N, Hansen TG, Weiss M, Ringer SK. Hypotension and Hypocapnia During General Anesthesia in Piglets: Study of S100b as an Acute Biomarker for Cerebral Tissue Injury. Journal of neurosurgical anesthesiology. 2019.

      2018 October: Effects of moderate and severe arterial hypotension on intracerebral perfusion and brain tissue oxygenation in piglets.

      Ringer SK, Clausen NG, Spielmann N, Ohlerth S, Schwarz A, Weiss M.
      Br J Anaesth. 2018 Dec;121(6):1308-1315. doi: 10.1016/j.bja.2018.07.041. Epub 2018 Oct 10.
      PMID: 30442258

      2018 August: Anesthesia and the developing brain: A way forward for laboratory and clinical research.

      Disma N, O’Leary JD, Loepke AW, Brambrink AM, Becke K, Clausen NG, De Graaff JC, Liu F, Hansen TG, McCann ME, Salorio CF, Soriano S, Sun LS, Szmuk P, Warner DO, Vutskits L, Davidson AJ.
      Paediatr Anaesth. 2018 Sep;28(9):758-763. doi: 10.1111/pan.13455. Epub 2018 Aug 16.
      PMID: 30117228

      2018 February: Systematic review of the neurocognitive outcomes used in studies of paediatric anaesthesia neurotoxicity.

      Clausen NG, Kähler S, Hansen TG.
      Br J Anaesth. 2018 Jun;120(6):1255-1273. doi: 10.1016/j.bja.2017.11.107. Epub 2018 Feb 3. Review.
      PMID: 29793593

      2017 December: Effectiveness of tip rotation in fibreoptic bronchoscopy under different experimental conditions: an in vitro crossover study.

      Piegeler T, Clausen NG, Weiss M.
      Br J Anaesth. 2017 Dec 1;119(6):1206-1212. doi: 10.1093/bja/aex322.
      PMID: 29028928

      2017 March: Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe.

      Habre W, Disma N, Virag K, Becke K, Hansen TG, Jöhr M, Leva B, Morton NS, Vermeulen PM, Zielinska M, Boda K, Veyckemans F; APRICOT Group of the European Society of Anaesthesiology Clinical Trial Network.
      Lancet Respir Med. 2017 May;5(5):412-425. doi: 10.1016/S2213-2600(17)30116-9. Epub 2017 Mar 28. Erratum in: Lancet Respir Med. 2017 May;5(5):e19. Lancet Respir Med. 2017 Jun;5(6):e22.
      PMID: 28363725>

      2016 April: Oral Clefts and Academic Performance in Adolescence: The Impact of Anesthesia-Related Neurotoxicity, Timing of Surgery, and Type of Oral Clefts.

      Clausen NG, Pedersen DA, Pedersen JK, Møller SE, Grosen D, Wehby GL, Christensen K, Hansen TG.
      Cleft Palate Craniofac J. 2017 Jul;54(4):371-380. doi: 10.1597/15-185. Epub 2016 Apr 4.
      PMID: 27043652

      2014: [Potential neurotoxicity of general anaesthetics to the developing brain].

      Clausen NG, Venø S, Astvad M, Henneberg SW, Christensen K, Hansen TG.
      Ugeskr Laeger. 2014;176(34). pii: V12120689. Review. Danish.
      PMID: 25293561

      2010 February: Risk scoring systems for adults admitted to the emergency department: a systematic review.

      Brabrand M, Folkestad L, Clausen NG, Knudsen T, Hallas J.
      Scand J Trauma Resusc Emerg Med. 2010 Feb 11;18:8. doi: 10.1186/1757-7241-18-8. Review.
      PMID: 20146829

      Curriculum Vitae:

      ADVANCED EDUCATION PROGRAM IN PAEDIATRIC ANAESTHESIA SEPTEMBER 2017 - AUGUST 2019

      An accordion content areaScandinavian Society of Anaesthesiology and Intensive Care Medicine, SSAI, coordinates an
      Inter-Nordic fellowship (training program) in Paediatric Anaesthesia and Intensive Care
      Medicine for young Scandinavian specialists in Anaesthesiology:
      • 24 months of training in paediatric anaesthesia and intensive care
      • 3 months (minimum) of paediatric intensive care medicine during the 2 years
      • 1 month of exchange in another county during the 2 years
      • 4 theoretical courses
      • Assessment after each theoretical course
      • Academic project
      During the 2 year training period, the following areas will be covered:
      • Neonatal anaesthesia
      • Anaesthesia for thoracic and cardiovascular surgery
      • Anaesthesia for orthopaedic surgery
      • Anaesthesia for neurosurgery
      • Anaesthesia outside the operation theatre
      • Management of a difficult airway
      • Management of central (epidural/sacral) and peripheral blocks
      • Management of acute and chronic pain

      RESEARCH ASSISTANT & FELLOW PEDIATRIC ANESTHESIA AT KINDERSPITAL ZÜRICH SEPTEMBER 2016 - APRIL 2018
      EMERGENCY PHYSICIAN APRIL 2015 - PRESENT
      Part time employment at various hospitals
      PHD FELLOW AT UNIVERSITY OF SOUTHERN DENMARK SEPTEMBER 2014 - DECEMBER 2018
      Study title:
      Long term outcome after general anaesthesia in newborns and infants: a Danish follow up study
      Hypothesis and outcomes:
      The current study aims to investigate, whether GA provided to children up to 1 year of age
      causes any long term damage to brain development. We will compare 1) school achievements,
      2) presence of psychiatric diagnoses, 3) handicaps of vision and hearing among children, who
      on one side have been through surgery and GA within their first year of life and on the other
      side to children, who have not.
      If GA causes brain damage, we expect these children
      – to have poorer grades at school at the national 9th grade exam
      – to be more often diagnosed with psychiatric diseases
      – to present with visual- and hearing-handicaps more often, than the children, they are
      compared to.
      Method:
      The relations mentioned above will be investigated merely by search on different Danish Civil
      Registers and linkage of these data. All children born in DK from 1986-1990 will be identified
      in the C R-register and linked to 5 different registers.
      We will adjust our data for those factors, that might influence school achievements,
      behavioural diagnoses and handicaps: parents’ age and education, the childrens birthweight,
      the condition the children needed treatment for in the first place.
      Advantages:
      The current study is much cheaper than clinical experiments.
      No harm is done to children, no inconvenience is imposed on parents or professionals.
      The data are already there, hence the results will be available within a reasonable time-frame.
      INSTRUCTOR 2014 - PRESENT
      Instructor Prospect as part of the Danish European Trauma Course (ETC)- team
      ANAESTHESIOLOGIST AT ODENSE UNIVERSITY HOSPITAL MAY 2013 - PRESENT
      Special field of interest: Paediatric anaesthesia, Orthopaedic anaesthesia, TraumaAssessment & –
      team training
      SENIOR REGISTRAR NOVEMBER 2011 - APRIL 2013
      DOCTOR (ANAESTHESIOLOGIST) NOVEMBER 2009 - OCTOBER 2011
      ANAESTHETIST NOVEMBER 2008 - OCTOBER 2009
      REGISTRAR FEBRUARY 2006 - NOVEMBER 2008
      AARHUS UNIVERSITET1995 - 2004
      Doctor of Medicine (MD)

      Curriculum Vitae:

      Odense University Hospital